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Utilizing a microRNA to shift the make-up of glioblastoma subtypes

Glioblastoma multiforme (GBM), an especially aggressive mind most cancers, is a really complicated illness. It's characterised by a fast-growing tumor within the mind composed of many subpopulations of cells, together with glioblastoma stem cells, which play an important position in glioblastoma initiation, growth and therapy-resistance. GBM's various make up -- termed heterogeneity -- is of medical significance as a result of it's a key issue that results in remedy failure, permitting the tumor to grow to be proof against remedy or for most cancers to recur. One strategy to establish totally different glioblastoma subtypes is by wanting on the particular microRNA expressed within the affected person derived GBM stem cells. In a number of kinds of most cancers cells, together with glioblastoma cells, microRNA expression is not regulated correctly. In a brand new examine printed in  Cell Reviews , BWH researchers examined a selected microRNA, miR-128, to assist es...

Scientists regenerate retinal cells in mice

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Glia are supportive cells within the retina. In zebrafish they'll endure modifications if the retina is injured. They then flip into quite a lot of cells to restore the retina. UW Medication researchers have now prompted glial cells to grow to be useful interneurons in mouse retinas. Credit score: Tom Reh lab/UW Medication Scientists have efficiently regenerated cells within the retina of grownup mice on the College of Washington Faculty of Medication in Seattle. Their outcomes elevate the hope that sometime it could be attainable to restore retinas broken by trauma, glaucoma and different eye illnesses. Their efforts are a part of the UW Medication Institute for Stem Cell and Regenerative Medication. Many tissues of our our bodies, akin to our pores and skin, can heal as a result of they include stem cells that may divide and differentiate into the kind of cells wanted to restore broken tissue. The cells of our retinas, nonetheless, lack this potential to regener...